Heat stroke
- Overview
- Theory
- Diagnosis
- Management
- Follow up
- Resources
Treatment algorithm
Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups: see disclaimer
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heat exhaustion
supportive care and oral rehydration
Mild volume depletion is can be defined as <3% loss of total body weight.[23]Tam N, Noakes TD. The quantification of body fluid allostasis during exercise. Sports Med. 2013 Dec;43(12):1289-99. http://www.ncbi.nlm.nih.gov/pubmed/23955577?tool=bestpractice.com Patients with mild volume depletion may experience symptoms and signs such as thirst or dry mucous membranes, although individual clinical findings are unreliable when taken in isolation.[24]McGee S, Abernethy WB 3rd, Simel DL. The rational clinical examination. Is this patient hypovolemic? JAMA. 1999 Mar 17;281(11):1022-9. http://www.ncbi.nlm.nih.gov/pubmed/10086438?tool=bestpractice.com [23]Tam N, Noakes TD. The quantification of body fluid allostasis during exercise. Sports Med. 2013 Dec;43(12):1289-99. http://www.ncbi.nlm.nih.gov/pubmed/23955577?tool=bestpractice.com All patients should be assessed using Advanced Trauma Life Support protocols and managed as appropriate.
The patient should be removed from the external heat source.
Oral rehydration should be given if the serum sodium is normal and fluid depletion exists.
Evaporative cooling can be encouraged by wetting the skin.
Core temperature and electrolyte balance are monitored.
1st line – supportive care and rehydration with isotonic intravenous fluids
supportive care and rehydration with isotonic intravenous fluids
All patients should be assessed using Advanced Trauma Life Support protocols and managed as appropriate.
The patient should be removed from the external heat source.
Evaporative cooling can be encouraged by wetting the skin.
It is essential that, if the patient is hyponatremic, hypotonic fluids are avoided.[19]Bennett BL, Hew-Butler T, Rosner MH, et al. Wilderness Medical Society clinical practice guidelines for the management of exercise-associated hyponatremia: 2019 update. Wilderness Environ Med. 2020 Mar;31(1):50-62. https://www.doi.org/10.1016/j.wem.2019.11.003 http://www.ncbi.nlm.nih.gov/pubmed/32044213?tool=bestpractice.com
All patients showing signs of significant volume depletion (such as severe postural dizziness, postural hypotension or tachycardia) or hyponatremia should be transferred to a medical facility for further assessment and management.[1]Glazer JL. Management of heatstroke and heat exhaustion. Am Fam Physician. 2005 Jun 1;71(11):2133-40. http://www.aafp.org/afp/2005/0601/p2133.html http://www.ncbi.nlm.nih.gov/pubmed/15952443?tool=bestpractice.com
Intravenous infusion of normal saline or Ringer lactate (Hartmann solution) should be given gradually.[18]Eifling KP, Gaudio FG, Dumke C, et al. Wilderness Medical Society clinical practice guidelines for the prevention and treatment of heat illness: 2024 update. Wilderness Environ Med. 2024 Mar;35(1 suppl):112S-27. https://www.doi.org/10.1177/10806032241227924 http://www.ncbi.nlm.nih.gov/pubmed/38425235?tool=bestpractice.com Infusions may require 1 to 1.5 L/hour. Patients with severe exercise-associated hyponatremia may require boluses of hypertonic 3% saline.[19]Bennett BL, Hew-Butler T, Rosner MH, et al. Wilderness Medical Society clinical practice guidelines for the management of exercise-associated hyponatremia: 2019 update. Wilderness Environ Med. 2020 Mar;31(1):50-62. https://www.doi.org/10.1016/j.wem.2019.11.003 http://www.ncbi.nlm.nih.gov/pubmed/32044213?tool=bestpractice.com
Core temperature and electrolyte balance are monitored.
heat stroke
1st line – urgent assessment and immediate external cooling
urgent assessment and immediate external cooling
Initial treatment of heat stroke in adults is aimed at rapidly decreasing core temperature. This may be initiated in the field, for example, by external cooling, before definitive diagnosis is made.
All patients should be assessed using Advanced Trauma Life Support protocols and managed as appropriate. If necessary patients should receive resuscitation using the ABCs of acute care (securing airway, breathing, and circulation).
Following transfer to a medical facility, cooling should be continued. External cooling methods include immersion and evaporative cooling.[1]Glazer JL. Management of heatstroke and heat exhaustion. Am Fam Physician. 2005 Jun 1;71(11):2133-40. http://www.aafp.org/afp/2005/0601/p2133.html http://www.ncbi.nlm.nih.gov/pubmed/15952443?tool=bestpractice.com [34]Harker J, Gibson P. Heat-stroke: a review of rapid cooling techniques. Intensive Crit Care Nurs. 1995 Aug;11(4):198-202. http://www.ncbi.nlm.nih.gov/pubmed/7670287?tool=bestpractice.com
Immersion cooling in an ice bath, or cooling blankets used in conjunction with ice packs to the axilla, groin, neck, and head, may be the most rapid methods of cooling.[25]Roberts WO, Armstrong LE, Sawka MN, et al. ACSM expert consensus statement on exertional heat illness: recognition, management, and return to activity. Curr Sports Med Rep. 2023 Apr 1;22(4):134-49. https://www.doi.org/10.1249/JSR.0000000000001058 http://www.ncbi.nlm.nih.gov/pubmed/37036463?tool=bestpractice.com [36]Newport M, Grayson A. Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 3: In patients with heatstroke is whole-body ice-water immersion the best cooling method? Emerg Med J. 2012 Oct;29(10):855-6. http://www.ncbi.nlm.nih.gov/pubmed/23038722?tool=bestpractice.com [37]McDermott BP, Casa DJ, Ganio MS, et al. Acute whole-body cooling for exercise-induced hyperthermia: a systematic review. J Athl Train. 2009 Jan-Feb;44(1):84-93. https://meridian.allenpress.com/jat/article/44/1/84/110882/Acute-Whole-Body-Cooling-for-Exercise-Induced http://www.ncbi.nlm.nih.gov/pubmed/19180223?tool=bestpractice.com Guidelines on exertional heat stroke recommend immediate cold water immersion (clothing/equipment removal is time consuming and should occur when the patient is in the tub).[25]Roberts WO, Armstrong LE, Sawka MN, et al. ACSM expert consensus statement on exertional heat illness: recognition, management, and return to activity. Curr Sports Med Rep. 2023 Apr 1;22(4):134-49. https://www.doi.org/10.1249/JSR.0000000000001058 http://www.ncbi.nlm.nih.gov/pubmed/37036463?tool=bestpractice.com [38]Casa DJ, DeMartini JK, Bergeron MF, et al. National Athletic Trainers' Association Position Statement: Exertional Heat Illnesses. J Athl Train. 2015 Sep;50(9):986-1000. https://www.doi.org/10.4085/1062-6050-50.9.07 http://www.ncbi.nlm.nih.gov/pubmed/26381473?tool=bestpractice.com
Patients cooled in an ice bath frequently experience afterdrop (where their core temperature continues to decline even after they are removed from the bath). To prevent iatrogenic hypothermia, patients are typically removed from the ice bath once their core temperature reaches 100°F (37.8°C).[1]Glazer JL. Management of heatstroke and heat exhaustion. Am Fam Physician. 2005 Jun 1;71(11):2133-40. http://www.aafp.org/afp/2005/0601/p2133.html http://www.ncbi.nlm.nih.gov/pubmed/15952443?tool=bestpractice.com [34]Harker J, Gibson P. Heat-stroke: a review of rapid cooling techniques. Intensive Crit Care Nurs. 1995 Aug;11(4):198-202. http://www.ncbi.nlm.nih.gov/pubmed/7670287?tool=bestpractice.com Practitioners should be aware of falsely elevated rectal temperatures due to the insulating effects of body mass.[42]Newsham KR, Saunders JE, Nordin ES. Comparison of rectal and tympanic thermometry during exercise. South Med J. 2002 Aug;95(8):804-10. http://www.ncbi.nlm.nih.gov/pubmed/12190213?tool=bestpractice.com Bradycardia due to the diving reflex is not uncommon, and immersion can make access to the patient difficult in case of a cardiac arrest.[1]Glazer JL. Management of heatstroke and heat exhaustion. Am Fam Physician. 2005 Jun 1;71(11):2133-40. http://www.aafp.org/afp/2005/0601/p2133.html http://www.ncbi.nlm.nih.gov/pubmed/15952443?tool=bestpractice.com
Evaporative cooling is where the patient's skin is exposed to warm air at 113°F (45°C) passing over the body while a mist of cool water at 59°F (15°C) speeds heat dissipation. Cooling rates with this technique have been measured at 0.5°F/minute (0.31°C/minute).[34]Harker J, Gibson P. Heat-stroke: a review of rapid cooling techniques. Intensive Crit Care Nurs. 1995 Aug;11(4):198-202. http://www.ncbi.nlm.nih.gov/pubmed/7670287?tool=bestpractice.com
Evaporative cooling may be preferred for older adult patients, or for those with compromised mental status, owing to the technical difficulties in performing resuscitation in an immersed patient.
rehydration with isotonic intravenous fluids
Treatment recommended for ALL patients in selected patient group
It is essential that, if a patient is hyponatremic, hypotonic fluids are avoided.[19]Bennett BL, Hew-Butler T, Rosner MH, et al. Wilderness Medical Society clinical practice guidelines for the management of exercise-associated hyponatremia: 2019 update. Wilderness Environ Med. 2020 Mar;31(1):50-62. https://www.doi.org/10.1016/j.wem.2019.11.003 http://www.ncbi.nlm.nih.gov/pubmed/32044213?tool=bestpractice.com
Intravenous infusion of normal saline or Ringer lactate (Hartmann solution) should be given gradually.[18]Eifling KP, Gaudio FG, Dumke C, et al. Wilderness Medical Society clinical practice guidelines for the prevention and treatment of heat illness: 2024 update. Wilderness Environ Med. 2024 Mar;35(1 suppl):112S-27. https://www.doi.org/10.1177/10806032241227924 http://www.ncbi.nlm.nih.gov/pubmed/38425235?tool=bestpractice.com Infusions may require 1 to 1.5 L/hour.
Patients with severe exercise-associated hyponatremia require boluses of hypertonic 3% saline.[19]Bennett BL, Hew-Butler T, Rosner MH, et al. Wilderness Medical Society clinical practice guidelines for the management of exercise-associated hyponatremia: 2019 update. Wilderness Environ Med. 2020 Mar;31(1):50-62. https://www.doi.org/10.1016/j.wem.2019.11.003 http://www.ncbi.nlm.nih.gov/pubmed/32044213?tool=bestpractice.com
internal cooling
Internal cooling methods are used if external cooling is not feasible or is ineffective. They are effective in rapidly decreasing temperature, although are more invasive than external cooling methods.
Gastric, bladder, and rectal cold water lavage can be readily performed. Peritoneal and thoracic lavage with cold isotonic fluid may also be used, but are more invasive and so are used only in extreme cases. Invasive body-cavity lavage techniques have not been adequately studied so should not be considered first-line treatment for heat stroke.[18]Eifling KP, Gaudio FG, Dumke C, et al. Wilderness Medical Society clinical practice guidelines for the prevention and treatment of heat illness: 2024 update. Wilderness Environ Med. 2024 Mar;35(1 suppl):112S-27. https://www.doi.org/10.1177/10806032241227924 http://www.ncbi.nlm.nih.gov/pubmed/38425235?tool=bestpractice.com Although rarely required, cardiopulmonary bypass or plasma exchange are also effective as cooling methods in this setting.[44]Raj VM, Alladin A, Pfeiffer B, et al. Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure. Pediatr Nephrol. 2013 Jun;28(6):971-4. https://link.springer.com/article/10.1007/s00467-013-2409-8 http://www.ncbi.nlm.nih.gov/pubmed/23338054?tool=bestpractice.com
rehydration with isotonic intravenous fluids
Treatment recommended for ALL patients in selected patient group
It is essential that, if a patient is hyponatremic, hypotonic fluids are avoided.[19]Bennett BL, Hew-Butler T, Rosner MH, et al. Wilderness Medical Society clinical practice guidelines for the management of exercise-associated hyponatremia: 2019 update. Wilderness Environ Med. 2020 Mar;31(1):50-62. https://www.doi.org/10.1016/j.wem.2019.11.003 http://www.ncbi.nlm.nih.gov/pubmed/32044213?tool=bestpractice.com
Intravenous infusion of normal saline or Ringer lactate (Hartmann solution) should be given gradually.[18]Eifling KP, Gaudio FG, Dumke C, et al. Wilderness Medical Society clinical practice guidelines for the prevention and treatment of heat illness: 2024 update. Wilderness Environ Med. 2024 Mar;35(1 suppl):112S-27. https://www.doi.org/10.1177/10806032241227924 http://www.ncbi.nlm.nih.gov/pubmed/38425235?tool=bestpractice.com Infusions may require 1 to 1.5 L/hour.
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Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups. See disclaimer
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