Approach
In general, symptomatic control is the mainstay of therapy for roseola and includes antipyretics and maintenance of oral hydration. Acetaminophen or ibuprofen can be given as needed.
Immunocompromised patients
Herpesvirus antiviral drugs, such as ganciclovir, valganciclovir, and foscarnet, have been used to treat human herpesvirus (HHV)-6 infection in patients who are immunocompromised and in infants with severe encephalitis; however, their efficacy has not been evaluated in clinical trials.[3][5] These antivirals are most commonly used in the solid organ and hematopoietic stem cell transplant patient population, due to morbidity from HHV-6 reactivation, including hepatitis, encephalitis, and graft rejection.[22][23]
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