Epidemiology

​In the US, 6% of women have metastatic breast cancer (MBC) when they are first diagnosed (i.e., de novo MBC).[4]​​

In 2018, the estimated prevalence of MBC in the US was 140,230.[5] Of these, 54,117 (38.6%) had de novo MBC, while 86,113 (61.4%) had an initial diagnosis of early or locally advanced breast cancer that subsequently progressed to MBC.[5]​ In 2030, there will be an estimated 246,194 prevalent cases of MBC in the US.[6]​​

The breast is the most common site of cancer in women worldwide, accounting for approximately 24.5% of all new cancers in women in 2020, with highest incidence rates in North America, Western and Northern Europe, and Australia/New Zealand.[4]​​​ 

In 2024, it is estimated that there will be approximately 310,720 new cases of female breast cancer in the US, and 42,250 deaths from breast cancer.[7]​​​ Breast cancer is most commonly diagnosed in middle-aged or older women; median age at diagnosis in women in the US is 63 years.​[8]

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