Criteria

Duration of infection

Standard infection:

  • Typically self-limiting symptoms, resolving by approximately 2 to 3 weeks

  • Complications may occur in certain patient populations (e.g., pregnant women and people with increased red blood cell turnover/destruction).

Persistent infection:

  • May occur in people with immunosuppression (e.g., patients with HIV, people receiving chemotherapy or immunosuppression following transplant, or patients with congenital immunodeficiencies)

  • May not present with classic erythema infectiosum, but with a chronic anemia

  • Antibodies to virus are usually absent with often high viral levels in the circulation

  • Symptoms last longer than the standard duration of infection, for example, at least 3 to 4 weeks.

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