Complications
Complication
Timeframe
Likelihood
short term
high
If left untreated, SCID is uniformly fatal in the first year of life.
variable
medium
Time frame of graft-versus-host disease can be subdivided into acute, subacute, and chronic phases. The likelihood of transplant-related complications is dependent on the timing of the transplantation and whether or not the transplant was human leukocyte antigen-matched.
Signs include rash, hepatosplenomegaly, and eosinophilia.[34]
variable
low
In the Primary Immune Deficiency Treatment Consortium study, 18% of the overall cohort required a second transplant within 5 years.[10] The risk was lowest among those who received a matched related donor hematopoietic stem cell transplantation.
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