Cochrane Clinical Answers

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Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.

  • What are the effects of pregabalin add‐on for people with drug‐resistant focal epilepsy?
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  • For adults with drug‐resistant focal epilepsy, what are the effects of adjunct eslicarbazepine acetate?
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  • What are the benefits and harms of lamotrigine add-on in adults or children with drug-resistant partial epilepsy?
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  • What are the effects of rufinamide as an adjunct to conventional antiepileptic drug (AED) therapy for people with refractory epilepsy?
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  • What are the effects of tiagabine add‐on therapy for people with drug‐resistant focal epilepsy?
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  • How does levetiracetam compare with other anti‐epileptic drugs in terms of congenital malformations in children?
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  • Do psychological treatments improve quality of life for people with epilepsy?
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  • For people with drug‐resistant epilepsy, how do different ketogenic diets compare?
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  • What are the effects of a ketogenic diet for people with drug‐resistant epilepsy?
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  • What are the benefits and harms of losigamone add‐on therapy for adults with focal epilepsy?
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