Primary hypothyroidism

Prognosis is generally excellent with full recovery upon adequate replacement of thyroid hormones. In a longitudinal study over 25 years, patients with treated hypothyroidism who maintained thyroid-stimulating hormone concentrations within normal limits had no difference in the pattern of long-term health outcomes.[55]Thayakaran R, Adderley NJ, Sainsbury C, et al. Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study. BMJ. 2019 Sep 3;366:l4892. https://www.doi.org/10.1136/bmj.l4892 http://www.ncbi.nlm.nih.gov/pubmed/31481394?tool=bestpractice.com The levothyroxine replacement dose may change over a period of years as the disease progresses or other conditions affecting thyroid hormone metabolism develop, but achieving excellent control of the disease is generally easily accomplished.