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Diabetic kidney disease

Diabetic kidney disease: mesangial expansion is usually recognized when it has exceeded 1.5 times the normal mesangial matrix

From the collection of Dr Raoul Fresco; used with permission

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Diabetic kidney disease

Diabetic kidney disease: at 5 o'clock - early Kimmelstiel-Wilson nodule, a rounded increase in mesangial matrix that probably originated in relation to a microaneurysm

From the collection of Dr Raoul Fresco; used with permission

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Diabetic kidney disease

Diabetic kidney disease: at 12 o'clock - early Kimmelstiel-Wilson nodule, a rounded form of mesangial expansion

From the collection of Dr Raoul Fresco; used with permission

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Diabetic kidney disease

Diabetic kidney disease: mesangial expansion due to increased mesangial matrix and decreased degradation of glycosylated collagen

From the collection of Dr Raoul Fresco; used with permission

See this image in context in the following section/s:

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