Anaphylaxis

Recurrence of anaphylaxis

Individuals with previous reactions are at higher risk for recurrence.[53]Cardona V, Ansotegui IJ, Ebisawa M, et al. World Allergy Organization anaphylaxis guidance 2020. World Allergy Organ J. 2020 Oct 30;13(10):100472. https://www.worldallergyorganizationjournal.org/article/S1939-4551(20)30375-6/fulltext http://www.ncbi.nlm.nih.gov/pubmed/33204386?tool=bestpractice.com However, the severity of the previous reaction does not necessarily predict the severity of a subsequent reaction.[39]Macdougall CF, Cant AJ, Colver AF. How dangerous is food allergy in childhood? The incidence of severe and fatal allergic reactions across the UK and Ireland. Arch Dis Child. 2002 Apr;86(4):236-9. http://adc.bmj.com/content/86/4/236.long http://www.ncbi.nlm.nih.gov/pubmed/11919093?tool=bestpractice.com The outlook will depend on the success of immunotherapy, allergen avoidance, and compliance with carrying their epinephrine (adrenaline) auto-injectors.

Cardiac arrest due to anaphylaxis

If the diagnosis is made early and the appropriate management is initiated promptly, the outcome of cardiac arrest in this population may be better. Still, serious sequelae of inadequate brain perfusion may occur and prognosis depends mainly on comorbidities and patient age.