Complications

Complication
Timeframe
Likelihood
short term
medium

Neurologic complications, such as encephalopathy, seizures, stroke, and coma, are seen in 25% of patients with HUS.[7][61][93]

short term
medium

Myocardial dysfunction, sometimes leading to congestive heart failure and pericardial effusions, may be seen.[94]

variable
medium

Intestinal complications such as perforation or bowel necrosis and pancreatitis are seen.[9]

In the postinfectious phase, patients can develop biliary lithiasis and colonic strictures.[95][96]

variable
low

Eculizumab is associated with an approximately 2000-fold increased incidence of meningococcal disease among people receiving the drug.[97]

Administration of meningococcal vaccines is recommended before beginning treatment with eculizumab.

Use of this content is subject to our disclaimer