Complications

Complication
Timeframe
Likelihood
variable
low

Occurs rarely in patients with type 3 VWD, usually in patients with large von Willebrand factor (VWF) gene deletions. May cause anaphylactic reactions to exogenous VWF. Successful treatment of bleeding with continuous infusion of high-purity factor VIII (recombinant or plasma derived) or with recombinant activated factor VII has been reported in these patients.[20][23]

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