Central hypothyroidism

Congenital hypothyroidism is included in the universal newborn screening panel in the US, Canada, and parts of Europe such as the UK. Screening methods vary at a national and international level.[44]Rose SR, Wassner AJ, Wintergerst KA, et al. Congenital hypothyroidism: screening and management. Pediatrics. 2023 Jan;151(1): e2022060419. https://publications.aap.org/pediatrics/article/151/1/e2022060419/190311/Congenital-Hypothyroidism-Screening-and-Management ​ The European Society for Pediatric Endocrinology and the European Society for Endocrinology recommend measurement of thyroid-stimulating hormone (TSH) as the most sensitive test for detecting primary congenital hypothyroidism. If the resources are available, adding measurement of total or free thyroxine (T4) to TSH is recommended to screen for central congenital hypothyroidism.[45]van Trotsenburg P, Stoupa A, Léger J, et al. Congenital hypothyroidism: a 2020-2021 consensus guidelines update – an ENDO-European Reference Network initiative endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology. Thyroid. 2021 Mar;31(3):387-419. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001676 http://www.ncbi.nlm.nih.gov/pubmed/33272083?tool=bestpractice.com The American Academy of Pediatrics recommends that any of the existing newborn screening strategies may be used, such as primary TSH, reflex T4 measurement; primary T4, reflex TSH measurement; or combined T4 and TSH measurement.[44]Rose SR, Wassner AJ, Wintergerst KA, et al. Congenital hypothyroidism: screening and management. Pediatrics. 2023 Jan;151(1): e2022060419. https://publications.aap.org/pediatrics/article/151/1/e2022060419/190311/Congenital-Hypothyroidism-Screening-and-Management ​

Serum thyroid function tests should be assessed regularly in patients with hypothalamic/pituitary disorders, including a history of radiation to the head.