History and exam
Key diagnostic factors
common
jaundice
The patient will have chronic jaundice.
dark-colored urine
Bilirubinuria is typically present.[23]
Other diagnostic factors
uncommon
fatigue
Some patients may describe mild symptoms such as fatigue.
abdominal pain
Some patients may describe mild symptoms such as vague abdominal pain.
Risk factors
weak
glucose-6-phosphate dehydrogenase deficiency
One case series reported RS coexistent with glucose-6-phosphate dehydrogenase (G6PD) deficiency, suggesting a possible interaction between co-inherited genes.[15]
beta-thalassemia
One case series reported RS coexistent with heterozygous beta-thalassaemia, suggesting a possible interaction between co-inherited genes.[15]
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