Prognosis

Even though schizophrenia has a relatively low prevalence when compared with other mental illnesses such as depression and anxiety, it contributes significantly to the global burden of disease. Schizophrenia is one of the leading causes of 'years lived with disability' according to the World Health Organization (WHO).[265]​ The mean life expectancy of a patient with schizophrenia is 14.5 years shorter, compared with the general population.[92]​ With currently available treatments, patients with schizophrenia often remain symptomatic and approximately 20% to 30% are considered treatment-resistant.[114]​ Varying percentages of clinical recovery (including the remission of symptoms), from 13.5% to 57%, have been reported.[266]

“Personal recovery” is increasingly recognized in mental health care and policy making. Personal recovery emphasizes a satisfying and hopeful life (including employment, meaningful relationships, community engagement), even within the limitations caused by schizophrenia.[267][268]

A comprehensive treatment plan that combines pharmacologic therapy and psychosocial interventions (including cognitive behavioral therapy [CBT], patient education, supported employment, and family intervention) leads to better recovery outcomes, such as vocational function, independent living, and meaningful social relationships, in addition to symptom stabilization.[269]​ 

Early detection and treatment for prodrome psychosis and first episode psychosis are associated with more favorable outcomes.[59]​[60][270][271]

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