Complications
May occur due to deterioration. Should be managed aggressively.[46]
May occur from dehydration or rhabdomyolysis.
Creatine kinase levels and hydration status should be carefully monitored.
Progressively high creatine kinase levels and myoglobinuria. Can be fatal.
Patients may need dialysis if rhabdomyolysis occurs.[59]
Secondary to immobility associated with catatonia or rigidity.
Secondary to obtundation or dysphagia.
Cognitive impairment has been reported. It is often difficult to distinguish from preexisting cognitive impairment (e.g., dementia, psychosis).[2]
The nervous system is very vulnerable to injury by hyperthermia, and in cases where body temperature has been extremely high or hyperthermia has persisted for a long time, patients have suffered permanent injury to the central nervous system or peripheral nerves.
Subsequent medication choices may be limited.
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