Epidemiology

CLL is the most common leukemia in the Western world.[5][6]​​​ It represents 1% of all new cancer cases in the US.[7] In 2024, it was estimated that there were approximately 20,700 new cases of CLL in the US, and 4440 CLL-related deaths.[7]

CLL is more common in men than in women (6.3 vs. 3.3 new cases per 100,000 persons, respectively; 2017-2021, age-adjusted US data). Median age at diagnosis in the US is 70 years; approximately 69% of diagnoses occur in people age ≥65 years.[7] Incidence is greatest in non-Hispanic white people (7.8 new cases per 100,000 males and 4.1 new cases per 100,000 females, respectively; 2017-2021, age-adjusted US data).[7]

In the UK, there were an estimated 3952 new cases of CLL each year, between 2017 and 2019.[8]

Although the incidence and prevalence of CLL in Asia, Latin America, and Africa is much lower than in the US, the clinical presentation, male-to-female ratio, and age group are similar.[9]

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