Prognosis

The prognosis in patients with sepsis and septic shock is guarded at best. The mortality rate from sepsis has been estimated in several studies to be between 28% and 50%.[207][208]​ One large prospective study in Europe observed an overall hospital mortality of 33%.[36] The Surviving Sepsis Campaign reported mortality to be 31% following a multifaceted intervention to facilitate compliance with guideline recommendations.[35]

Intensive care setting (ICU)-specific mortality has been shown to be 27% to 32% in patients with sepsis, and 50% to 70% in patients with septic shock, compared with 14% in ICU patients without sepsis.[38][140]

Multiorgan compromise is common in advanced sepsis with variable residual morbidity.[38][81]

Risk factors (at index hospitalization) associated with longer-term mortality in a cohort of adult sepsis survivors included male sex, having one or more severe comorbidities, having some or total dependency prior to critical care admission, and longer index hospital length of stay.[209]

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