Amphetamine and methamphetamine use disorder

Relapse

Patients have a high probability of repeated use of stimulants after documented acute use, or of documented stimulant use disorder. Holistic psychological and sociological interventions to change lifestyle and treat addiction may help to reduce the high relapse rate. Effective management strategies typically incorporate long-term continuing care in addition to short-term management of exacerbations/relapses.[67]McKay JR. Impact of continuing care on recovery from substance use disorder. Alcohol Res. 2021 Jan 21;41(1):01. https://arcr.niaaa.nih.gov/volume/41/1/impact-continuing-care-recovery-substance-use-disorder http://www.ncbi.nlm.nih.gov/pubmed/33500871?tool=bestpractice.com [68]Iturralde E, Weisner CM, Adams SR, et al. Patterns of health care use 5 years after an intervention linking patients in addiction treatment with a primary care practitioner. JAMA Netw Open. 2022 Nov 1;5(11):e2241338. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2798247 http://www.ncbi.nlm.nih.gov/pubmed/36355373?tool=bestpractice.com

Remission rates from dependence vary depending on study and definition, but range from around 0.45 to 0.16.[128]Calabria BD, Degenhardt L, Briegleb C, et al. Systematic review of prospective studies investigating "remission" from amphetamine, cannabis, cocaine or opioid dependence. Addict Behav. 2010 Aug;35(8):741-9. http://www.ncbi.nlm.nih.gov/pubmed/20444552?tool=bestpractice.com