Complications
Both disseminated intravascular coagulation (DIC) and its underlying disorders can lead to acute renal failure and multiple organ failure. Uncontrolled systemic activation of coagulation systems results in widespread intravascular thrombosis, leading to organ ischemia and failure. Other contributing factors include organ hemorrhage, toxins, hypovolemia, hypotension, and hypoxemia. Early aggressive treatment of both the underlying disease and DIC is the key to reducing mortality.
This is a late complication of DIC, resulting from depletion of coagulation factors and platelets. Replacement of depleted coagulation factors/platelets and blood loss, and active treatment of the underlying condition and DIC, are required. Antifibrinolytic agents, such as aminocaproic acid or tranexamic acid, may be cautiously considered if bleeding is resistant to replacement therapy.[1][2][10][17]
Early identification and prompt intervention likely improve the outcomes for these severe bleeding complications.
Gangrene and loss of digits result from ischemia due to thrombosis.
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