Hypercholesterolemia

A reduced intake of saturated fats and cholesterol should be advised, as well as increased consumption of dietary fiber, complex carbohydrates, and unsaturated and monounsaturated fats.[31]Lichtenstein AH, Appel LJ, Vadiveloo M, et al. 2021 dietary guidance to improve cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2021 Dec 7;144(23):e472-87. https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001031?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org http://www.ncbi.nlm.nih.gov/pubmed/34724806?tool=bestpractice.com

Aerobic exercise, at least 3 times a week, is recommended. US and European guidelines now recommend 150-300 minutes per week of moderate-intensity exercise, or 75-150 minutes per week of high-intensity exercise, in primary and secondary cardiovascular prevention.[41]Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020 Jan 1;41(1):111-88. https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehz455/5556353 http://www.ncbi.nlm.nih.gov/pubmed/31504418?tool=bestpractice.com [59]Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease. 2019 Sep 10;140(11):e596-646. https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000000678 http://www.ncbi.nlm.nih.gov/pubmed/30879355?tool=bestpractice.com ​ 

Patients on statins should be encouraged to notify their healthcare professional immediately about any of the following symptoms of liver problems: unusual fatigue or weakness, loss of appetite, upper belly pain, dark-colored urine, or yellowing of the skin or the whites of the eyes.[141]US Food and Drug Administration. FDA drug safety communication: important safety label changes to cholesterol-lowering statin drugs. Jan 2016 [internet publication]. https://www.fda.gov/Drugs/DrugSafety/ucm293101.htm