Epidemiology

In Europe, adult immune thrombocytopenia (ITP) has an incidence of 1.6 to 3.9 cases in 100,000 per year.[4] Incidence increases with older age and there is a higher female-to-male ratio (3:1) in younger patients. A nationwide population study in the UK reported a crude incidence of 3.9 cases in 100,000 person-years, with a higher incidence in women.[5] A nationwide population study in France reported an incidence of 2.9 cases (of ITP necessitating health care) in 100,000 per year.[6] ITP was secondary to other disease in 18% of cases.[6] Childhood ITP has an incidence of between 1.9 and 6.4 in 100,000 per year with equal distribution between the sexes, and tends to result in spontaneous remission.[4]

Data on epidemiology from the US and other countries is lacking. One study of two US private healthcare claims databases from 2012 to 2015 estimated an annual incidence of 6.1 cases per 100,000 population. Incidence was higher for women (6.7 per 100,000) than for men (5.5 per 100,000), and highest in children ages 0-4 years (6.1 per 100,000) and adults ages ≥65 years (13.7 per 100,000).[7]​ The prevalence of ITP has been estimated as between 9.6 and 20.0 in 100,000 in the US, based on insurance administrative data, with​​ higher prevalence with increasing age and among female adults.[8][9]

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