Prognosis
Medical observation
For asymptomatic patients who do not meet the criteria for surgical intervention, 75% have stable disease for up to 10 years. Twenty-five percent of patients progress to meeting criteria for parathyroidectomy. However, younger patients (patients <50 years of age) tend to progress to meeting criteria for parathyroidectomy in up to 70%.[97] The most common cause of death of patients with PHPT is cardiovascular in origin (stroke, myocardial infarction). Hypercalcemic dysrhythmias are rare.
Parathyroidectomy
Parathyroidectomy has a biochemical cure rate of around 98% for experienced endocrine surgeons.[1] In one large cohort study bone mineral density improved in 58% of those who had post-operative measurements, and overall more than 85% of patients were satisfied with the results of their procedure.[98]
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