Prognosis

Malignant pleural mesothelioma remains a highly lethal malignancy despite treatment advances and the advent of multimodal therapy (e.g., surgery, chemotherapy, immunotherapy, radiation therapy). Surgical treatment in addition to systemic chemotherapy is independently associated with improved overall survival in patients with operable malignant pleural mesothelioma; older age, male sex, African-American race, low income, and low educational attainment are associated with poor overall survival in patients with operable disease.[55]

1-year relative survival rate (based on 2019 data) for people with mesothelioma in the US (stage at diagnosis):[54]

  • 62.7% (localized disease)

  • 62.3% (regional)

  • 47.4% (distant).

5-year relative survival rate (based on 2015 data) for people with mesothelioma in the US (stage at diagnosis):[54]

  • 24.2% (localized disease)

  • 15.7% (regional)

  • 9.4% (distant).

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