Prognosis

Untreated FMF may cause secondary amyloidosis (potentially fatal), suppressed growth, miscarriage, and infertility. Colchicine has been shown to reduce these risks, as well as preventing flares.[46][108][109][113][114] Colchicine nonresponders, protracted myalgia, or arthritis may be treated with certain biologic treatments, but more clinical evidence is needed before such treatments become first-line options for such potentially painful and destructive complications.[104] In the future, it may be possible to identify those who might respond to specific biologic therapies based on specific markers or genetic testing.

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