Evaluation of seronegative arthritis

oligoarticular involving large joints or polyarticular inflammatory joint involvement, inflammatory back pain

synovitis, spine involvement, enthesitis: dactylitis or tenderness at entheseal insertions such as the Achilles tendon and plantar fascia insertions; extra-articular manifestations: uveitis, psoriasis, keratoderma blennorrhagica, erythema nodosum

scalp or nail problems, joint pain and stiffness, pain at site of tendon attachment, spinal stiffness

peripheral arthritis, dactylitis, reduction of cervical spine mobility

oligoarticular involving large joints or polyarticular inflammatory joint involvement

synovitis, spine involvement, enthesitis: dactylitis or tenderness at entheseal insertions such as the Achilles tendon and plantar fascia insertions; extra-articular manifestations: uveitis, psoriasis, keratoderma blennorrhagica, erythema nodosum; urethritis in males and mucopurulent cervicitis in females with sexually acquired reactive arthritis[77]Carlin E, Marzo-Ortega H, Flew S. British Association of Sexual Health and HIV national guideline on the management of sexually acquired reactive arthritis 2021. Int J STD AIDS. 2021 May 20;:9564624211020266. https://www.doi.org/10.1177/09564624211020266 http://www.ncbi.nlm.nih.gov/pubmed/34014782?tool=bestpractice.com

oligoarticular involving large joints or polyarticular inflammatory joint involvement, inflammatory back pain

synovitis, spine involvement, enthesitis: dactylitis or tenderness at entheseal insertions such as the Achilles tendon and plantar fascia insertions; extra-articular manifestations: uveitis, psoriasis, keratoderma blennorrhagica, erythema nodosum

may present in 4 patterns: pseudo-rheumatoid arthritis, osteoarthritis with synovitis, pseudogout, and monoarthropathy

synovitis, tophaceous deposits at the extensor surfaces and ears

acute onset, <50 years of age, severe joint pain

synovitis, tophaceous deposits at the extensor surfaces and ears

fever, night sweats; pain and stiffness of the shoulders and pelvic girdle that are most severe in the morning and last several hours

palpable synovitis in knees, wrists, MCP joints; edema, decreased active range of motion of shoulders, neck, hips

pain, functional difficulties, stiffness

hand, hip, and knee involvement, bony deformities particularly in the hands, tenderness, limited range of motion; bony malalignment is common, particularly in the knee

complaints of multiple joint pain and swelling accompanied by early morning stiffness lasting for more than 1 hour

symmetric polyarthritis with wrist and small joint involvement

young female with arthralgia, photosensitive rash, alopecia, mouth ulcers, pleurisy

small to medium joint polyarthritis, malar rash, hard palate ulcers, alopecia

usually acute monoarticular joint involvement, fever; risk factors: age >80 years, diabetes mellitus, history of rheumatoid arthritis, joint surgery, hip or knee prosthesis, skin infection, immunodeficiency

swollen, tender joint; rarely polyarticular

often insidious onset; chills, malaise, weight loss, night sweats, shortness of breath, leg edema, hemisensory/motor deficit, arthralgia; history of rheumatic fever, recent dental work, prosthetic valve, intravenous drug use, or prior subacute bacterial endocarditis

new murmur, signs of congestive heart failure or peripheral emboli (splinter hemorrhages, Osler nodes, Janeway lesions), Roth spots or retinal hemorrhages, focal neurologic deficit

acute polyarthritis, may be fever; parvovirus B19 infection presents acutely with polyarticular symmetrical arthralgia without significant swelling; may be risk factors for specific infections, history of travel in Southeast Asia, the Caribbean, or South America, and mosquito bite with chikungunya virus infection; a minority of people with chikungunya infection go on to develop chronic symptoms

multiple tender joints without significant synovial effusion; may be skin rash: for example, morbilliform rash, hyperpigmentation, and intertriginous lesions with chikungunya virus infection

abdominal pain, diarrhea, fever, fatigue, lower gastrointestinal bleeding, altered bowel habit, loss of appetite, weight loss

joint inflammation, uveitis, abdominal mass or tenderness, rectal fistula, positive fecal occult blood test

men >50 years of age, acute-onset polyarthritis

bilateral hand pitting edema, synovitis

often in young black women, dyspnea, cough, uveitis, fever, fatigue, weight loss

rarely neck lymphadenopathy, otherwise may be normal

periodic, transient fevers associated with rapid rash onset; rash disappears as the fever remits; arthritis and myalgia commonly present

fever, salmon-pink macular rash, favors the trunk and sites of pressure; joint pain, inflammation commonly affecting knees, ankles (juvenile), and carpals (adults)

arthralgias, myalgias, photosensitive rash, alopecia, mouth ulcers, pleurisy, fatigue, dry eyes, dry mouth, painless loss of function of hands, heartburn, reflux and dysphagia, weight loss, swelling of the hands and feet, dyspnea, difficulty with motor tasks, fatigue and generalized malaise, proximal muscle weakness, pruritus, fever

arthritis, basal crepitations, sclerodactyly, sclerodermatous skin changes, lymphadenopathy[12]Klippel JH, Dieppe PA, eds. Rheumatology. 2nd ed. London, UK: Mosby International; 1998.

fatigue, dry eyes, dry mouth, arthralgia, myalgia

arthritis, dental caries, corneal ulceration, no saliva pool, enlarged salivary glands

painless loss of function of hands, heartburn, reflux and dysphagia, weight loss, arthralgias and myalgias, fatigue, swelling of the hands and feet, dyspnea

sclerodactyly, skin thickening, digital pits or ulcers, Raynaud phenomenon, abnormal nail-fold capillaroscopy, subcutaneous calcinosis

difficulty with motor tasks, fatigue and generalized malaise, shortness of breath, weight loss, dysphagia, arthralgia, myalgia

muscle weakness, muscle atrophy

proximal muscle weakness, pruritus, fatigue and malaise, fever, arthralgia, myalgia, dyspnea, weight loss

Gottron papules, heliotrope rash with or without periorbital edema, macular violaceous erythema; periungual erythema, nail-fold capillary dilation, cuticular overgrowth, "mechanic's" hands, photosensitivity, poikiloderma vasculare atrophicans

arthralgia, constitutional symptoms, purpura, abdominal pain, cutaneous ulcers, hemoptysis, headache and scalp tenderness

asymmetric brachial pulses, bruit, visual changes, hematuria, foot drop, wrist drop

in disseminated gonococcal infection: knees, wrists, ankles, and elbows are most affected; tenosynovitis in hands, ankles, knees, and feet

swollen, tender joint; rarely polyarticular, dermatitis may present as a maculopapular or a vesicular rash

fever, migratory arthritis, Sydenham chorea, epistaxis, abdominal pain; heart involvement may be asymptomatic or cause chest pain, dyspnea

joint swelling, ring- or snake-shaped skin eruptions on the trunk and upper arms and legs, skin nodules, pericardial friction rub, murmur

fever, lethargy, headache, myalgia, neck stiffness, inflammation of large joints[29]Lantos PM, Rumbaugh J, Bockenstedt LK, et al. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Care Res (Hoboken). 2021 Jan;73(1):1-9. http://www.ncbi.nlm.nih.gov/pubmed/33251700?tool=bestpractice.com

erythema migrans: bulls-eye lesion(s)

arthralgia, fever, diarrhea

skin hyperpigmentation, lymphadenopathy, oligo- or polyarthritis

osteoarticular tuberculosis (TB): back pain; hip, knee, or hand pain; or pain due to underlying osteomyelitis

decreased, painful range of motion of the spine and hip; tender swelling of knee; hand pain and swelling

asymmetric distribution, affliction of predominantly lower extremities, pain, constitutional symptoms; most commonly associated with breast, colon, lung, ovarian, gastric, and esophageal cancers, and lymphoproliferative disorders[36]Andras C, Csiki Z, Ponyi A, et al. Paraneoplastic rheumatic syndromes. Rheumatol Int. 2006;26:376-382. http://www.ncbi.nlm.nih.gov/pubmed/16091919?tool=bestpractice.com [37]Racanelli V, Prete M, Minoia C, et al. Rheumatic disorders as paraneoplastic syndromes. Autoimmun Rev. 2008;7:352-358. http://www.ncbi.nlm.nih.gov/pubmed/18486921?tool=bestpractice.com

hepatosplenomegaly, lymphadenopathy, synovitis

constitutional symptoms, extreme pain, monoarticular or polyarticular concurrent with non-Hodgkin lymphoma, acute and chronic leukemia; no response to conventional therapy

asymmetric distribution, affliction of predominantly lower extremities, synovitis, hepatosplenomegaly, lymphadenopathy