Mumps

Centers for Disease Control and Prevention (CDC) 2024 case definition[42]Centers for Disease Control and Prevention. National notifiable diseases surveillance system (NNDSS): mumps 2024 case definition. Feb 2024 [internet publication]. https://ndc.services.cdc.gov/case-definitions/mumps ​​

Clinical criteria

In the absence of a more likely alternative diagnosis, an acute sickness characterized by:

• Parotitis or swelling of other (nonparotid) salivary gland(s) of any duration, OR

• At least one of the following mumps-associated complication(s):

  • Orchitis

  • Oophoritis

  • Aseptic meningitis

  • Encephalitis

  • Hearing loss

  • Mastitis

  • Pancreatitis

Laboratory criteria

Confirmatory Laboratory Evidence:

• Positive reverse transcriptase polymerase chain reaction (RT-PCR) for mumps-specific nucleic acid, OR

• Isolation of mumps virus, OR

• Significant rise (i.e., at least a 4-fold rise in a quantitative titer or seroconversion) in paired acute and convalescent serum mumps immunoglobulin G (IgG) antibody

Supportive Laboratory Evidence:

• Positive test for serum mumps immunoglobulin M (IgM) antibody

Epidemiologic linkage

• Exposure to or contact with a confirmed mumps case, OR

• Member of a group or population identified by public health authorities as being at increased risk for acquiring mumps because of an outbreak.

Case Classification

Suspect

• Meets the clinical criteria but does not meet laboratory or epidemiologic linkage criteria, OR

• Meets supportive laboratory evidence but does not meet the clinical criteria AND has documentation that mumps was suspected.

Probable

• Meets clinical criteria AND epidemiologic linkage criteria, OR

• Meets supportive laboratory evidence AND

• Meets clinical criteria of:

  • ≥2-day duration of parotitis or other salivary gland swelling OR

  • a mumps-related complication.

AND

• Does not meet epidemiologic linkage criteria (these are considered sporadic cases).

Confirmed

• Meets confirmatory laboratory evidence.