Cochrane Clinical Answers

Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.
- Can prophylactic antibiotics help to prevent pneumococcal infection in children with sickle cell disease?
- Are psychological interventions for chronic and recurrent non‐headache pain effective in children and adolescents?
- What are the effects of blood transfusion for preventing stroke in children and adolescents with sickle cell disease?
- What are the effects of red blood cell transfusions for preventing silent cerebral infarcts among children with sickle cell disease?
- For people with sickle cell disease, how does red blood cell (RBC) transfusion compare with supportive care or use of disease‐modifying agents?
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