Epidemiology
In Europe, the estimated incidence of membranous nephropathy (MN) is 2 to 17 cases per million per year.[2] In the US, the estimated incidence of MN is 10 to 12 cases per million per year.[1][3] In contrast to other primary glomerular diseases, the incidence of MN has remained constant since the 1980s.[4] MN is one of the most common causes of nephrotic syndrome globally, just behind focal segmental glomerular sclerosis, which is the most common cause in some populations.[2] MN affects people of all ages and races, but the mean age at diagnosis is between 50 and 60 years and there is a 2:1 male predominance.[1][2] MN is rare in the paediatric population; however, the diagnosis may be underestimated as children with nephrotic syndrome are usually treated empirically without performing a renal biopsy.[2]
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