Monitoring
Patients with mixed cryoglobulinaemia should be followed clinically and with laboratory testing for evidence of organ involvement. Patients who are asymptomatic or with minimal symptoms should be monitored every 2-3 months for manifestations of cryoglobulinaemia such as ulcers, acrocyanosis, digital gangrene, and purpura, and complications of chronic hepatitis C virus infection.
The interval of medical assessment depends on the previous extent of organ involvement and the relative stability of the patient. Cryoglobulin levels, rheumatoid factor, or complement C4 levels are generally not used to follow up patients because they do not correlate with disease activity.[1][2][4]
Monitoring for malignancies in patients with chronic viral hepatitis is recommended.[53] If a patient is diagnosed with a haematological malignancy while being evaluated for cryoglobulinaemia, referral to a haematologist is imperative.
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