The localised reaction to bed bug bites is self-limiting, typically lasting days to weeks.[2]Parola P, Izri A. Bedbugs. N Engl J Med. 2020 Jun 4;382(23):2230-7.
http://www.ncbi.nlm.nih.gov/pubmed/32492304?tool=bestpractice.com
[37]Ter Poorten MC, Prose NS. The return of the common bedbug. Pediatr Dermatol. 2005 May-Jun;22(3):183-7.
http://www.ncbi.nlm.nih.gov/pubmed/15916561?tool=bestpractice.com
Recurrence of lesions depends on whether infestation is cleared from the living environment. As an individual gets bitten repeatedly, he or she is more likely to have more intense reactions.[22]Krause-Parello CA, Sciscione P. Bedbugs: an equal opportunist and cosmopolitan creature. J Sch Nurs. 2009 Apr;25(2):126-32.
http://www.ncbi.nlm.nih.gov/pubmed/19233933?tool=bestpractice.com
[38]Fletcher CL, Ardern-Jones MR, Hay RJ. Widespread bullous eruption due to multiple bed bug bites. Clin Exp Dermatol. 2002 Jan;27(1):74-5.
http://www.ncbi.nlm.nih.gov/pubmed/11952681?tool=bestpractice.com