Emerging treatments

Probiotics

Probiotics such as Lactobacillus reuteri may be of benefit in infants with colic.[41][42][43][44]​​​ Systematic reviews report reduced crying time, particularly in breastfed infants.[32][41]​​[44][45][46][47]​​​​​​​​​​ However, a 2019 Cochrane review concluded that there is no clear evidence that probiotics are more effective than placebo at preventing infantile colic.[45] [ Cochrane Clinical Answers logo ] [Evidence C]​ Based on this Cochrane review, UK guidance does not recommend the use of probiotics for infants with colic.[48] However, guidance in Australia, Canada, and Middle-Eastern countries recommend considering L reuteri DSM 17938 as a treatment option for colic in exclusively breastfed infants.[49][50][51]​​​

Low-FODMAP diet

In one randomised crossover trial of breastfeeding mothers, a low-FODMAP maternal diet was associated with reduced crying-fussing duration of infants with colic compared with a typical western diet.[52] The effect appeared to be independent of changes in maternal anxiety and stress. 

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