RLS of any severity occurs in 5% to 15% of European and North American adults.[6]Ohayon MM, O'Hara R, Vitiello MV. Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev. 2012 Aug;16(4):283-95.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204316
http://www.ncbi.nlm.nih.gov/pubmed/21795081?tool=bestpractice.com
[8]Yeh P, Walters AS, Tsuang JW. Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath. 2012 Dec;16(4):987-1007.
http://www.ncbi.nlm.nih.gov/pubmed/22038683?tool=bestpractice.com
[9]Ohayon MM, Bagai K, Roberts LW, et al. Refining duration and frequency thresholds of restless legs syndrome diagnosis criteria. Neurology. 2016 Dec 13;87(24):2546-53.
http://www.ncbi.nlm.nih.gov/pubmed/27770066?tool=bestpractice.com
1.5% to 2.7% have symptoms which occur at least twice a week and result in moderate or severe distress.[10]Allen RP, Bharmal M, Calloway M. Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States. Mov Disord. 2011 Jan;26(1):114-20.
http://www.ncbi.nlm.nih.gov/pubmed/21322022?tool=bestpractice.com
[11]Allen RP, Stillman P, Myers AJ. Physician-diagnosed restless legs syndrome in a large sample of primary medical care patients in western Europe: Prevalence and characteristics. Sleep Med. 2010 Jan;11(1):31-7.
http://www.ncbi.nlm.nih.gov/pubmed/19464949?tool=bestpractice.com
RLS prevalence is higher in women than in men.[6]Ohayon MM, O'Hara R, Vitiello MV. Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev. 2012 Aug;16(4):283-95.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204316
http://www.ncbi.nlm.nih.gov/pubmed/21795081?tool=bestpractice.com
This is thought to be predominantly due to the higher prevalence of RLS in pregnancy.[12]Pantaleo NP, Hening WA, Allen RP, et al. Pregnancy accounts for most of the gender difference in prevalence of familial RLS. Sleep Med. 2010 Mar;11(3):310-3.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830334
http://www.ncbi.nlm.nih.gov/pubmed/19592302?tool=bestpractice.com
Studies indicate a lower prevalence in Asia and Africa, as well as among Hispanic populations.[5]Picchietti DL, Van Den Eeden SK, Inoue Y, et al. Achievements, challenges, and future perspectives of epidemiologic research in restless legs syndrome (RLS). Sleep Med. 2017 Mar;31:3-9.
http://www.ncbi.nlm.nih.gov/pubmed/27567163?tool=bestpractice.com
Mean age of onset is during the third and fourth decades, but it can occur at any age, including in children, with an estimated prevalence of 2% to 4% in paediatric populations and 0.5% to 1% reporting moderate to severe symptoms.[5]Picchietti DL, Van Den Eeden SK, Inoue Y, et al. Achievements, challenges, and future perspectives of epidemiologic research in restless legs syndrome (RLS). Sleep Med. 2017 Mar;31:3-9.
http://www.ncbi.nlm.nih.gov/pubmed/27567163?tool=bestpractice.com
Prevalence increases with age in European and North American countries but not in Asian countries.[6]Ohayon MM, O'Hara R, Vitiello MV. Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev. 2012 Aug;16(4):283-95.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204316
http://www.ncbi.nlm.nih.gov/pubmed/21795081?tool=bestpractice.com