Gastroparesis has been associated with a significant decrease in quality of life and psychosocial comorbidities such as anxiety and depression.[68]Schol J, Wauters L, Dickman R, et al. United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis. United European Gastroenterol J. 2021 Apr;9(3):287-306.
https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12060
http://www.ncbi.nlm.nih.gov/pubmed/33939892?tool=bestpractice.com
The overall survival of patients with gastroparesis appears to be lower compared to their age and sex-expected survival.[8]Jung HK, Choung RS, Locke GR 3rd, et al. The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006. Gastroenterology. 2009 Apr;136(4):1225-33.
https://www.gastrojournal.org/article/S0016-5085(08)02305-6/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/19249393?tool=bestpractice.com
The outlook depends on the aetiology. Diabetic and post-surgical gastroparesis are chronic conditions. Symptoms can be well controlled in most patients with a judicious combination of prokinetics, anti-emetics, nutritional support, and strict glycaemic control in patients with diabetes. Some patients do not respond to this treatment approach and continue to have repeated admissions to hospital for refractory nausea and vomiting, dehydration, and malnutrition. Patients with idiopathic or post-viral gastroparesis can follow a similar clinical course; however, there is a potential for recovery and normalisation of gastric function over a period of many months or years.[122]Tack J. Gastric motor disorders. Best Pract Res Clin Gastroenterol. 2007;21(4):633-44.
http://www.ncbi.nlm.nih.gov/pubmed/17643905?tool=bestpractice.com
[123]Lacy BE, Weiser K. Gastrointestinal motility disorders: an update. Dig Dis. 2006;24(3-4):228-42.
http://www.ncbi.nlm.nih.gov/pubmed/16849850?tool=bestpractice.com
[124]Thorn AR. Not just another case of nausea and vomiting: a review of postinfectious gastroparesis. J Am Acad Nurse Pract. 2010 Mar;22(3):125-33.
http://www.ncbi.nlm.nih.gov/pubmed/20236395?tool=bestpractice.com