Hydrogen peroxide topical solution
Hydrogen peroxide topical solution (40%) has proven effective in the treatment of raised seborrhoeic keratoses, and the US Food and Drug Administration has approved its use for this indication.[34]Murphy EC, Friedman AJ. Hydrogen peroxide topical solution, 40% (w/w) for the treatment of seborrheic keratoses: a review. Skin Therapy Lett. 2020 Jan;25(1):1-4.
https://www.skintherapyletter.com/seborrheic-keratoses/hydrogen-peroxide-topical-solution
http://www.ncbi.nlm.nih.gov/pubmed/32023021?tool=bestpractice.com
Significantly more seborrhoeic keratoses lesions completely or nearly cleared with the use of this solution compared to placebo in phase 3 studies (study 1, 47% versus 10%; study 2, 54% versus 5%) that included a total of 937 individuals.[35]Baumann LS, Blauvelt A, Draelos ZD, et al. Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302). J Am Acad Dermatol. 2018 Jun 1;79(5):869-877.
https://www.doi.org/10.1016/j.jaad.2018.05.044
http://www.ncbi.nlm.nih.gov/pubmed/29864467?tool=bestpractice.com
[36]Funkhouser CH, Coerdt KM, Haidari W, et al. Hydrogen peroxide 40% for the treatment of seborrheic keratoses. Ann Pharmacother. 2021 Feb;55(2):216-221.
http://www.ncbi.nlm.nih.gov/pubmed/32646224?tool=bestpractice.com
The solution was applied at the start of the study and, if needed, was reapplied 3 weeks later. Common adverse effects at the application site included itching, stinging, crusting, swelling, redness and scaling.