Complications
Symptoms can be absent, but if present, may include malaise or fatigue. Laboratory abnormalities include low potassium and/or magnesium and elevation of creatinine. Serum levels of creatinine, potassium, and magnesium should be assessed frequently (daily to weekly) while on treatment. Amphotericin can be held temporarily and electrolytes should be quickly replaced.
Symptoms include fever, chills, and phlebitis.
Can treat or pretreat with paracetamol, antihistamines, or hydrocortisone.
Rigors may respond also to pethidine.
Decompression using a shunt is needed to treat the increased intracranial pressure.[5]
Azole antifungal treatment does not necessarily require change of regimen.
A cavity that ruptures into the pleural space causes a pyopneumothorax.
Surgical resection with decortication and antifungal therapy is the recommended management strategy.[5]
Fluconazole and itraconazole are preferred antifungal treatments, but amphotericin-B can be used if the patient cannot tolerate azoles or requires two or more surgical procedures for control.[5]
Duration of treatment is 3 to 6 months or longer, depending on risk factors for dissemination, presence of immunosuppression, and the serological response to interventions.
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