Images and videos

Images

25

Assessment of solitary pulmonary nodule

Computed tomography (CT) section capturing the transthoracic core biopsy needle targeting a left lower lobe lobulated nodule. Histopathology confirmed a well-differentiated squamous cell lung cancer

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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2

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a right upper lobe apical solid nodule with a surrounding ‘ground glass’ halo, in a patient with seropositive rheumatoid arthritis on methotrexate. Other similar nodules were seen throughout both lungs, and remain stable for >2 years, consistent with inflammatory benign rheumatoid nodules

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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6

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a right lower lobe large nodule, with contrast enhancement and a clear feeding and draining side, consistent with an arteriovenous malformation

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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10

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a left upper lobe ground-glass nodule. This was eventually resected 2 years into surveillance because of growth and the histopathology confirmed adenocarcinoma of lung with mixed mucinous-lepidic pattern

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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13

Assessment of solitary pulmonary nodule

Computed tomography (CT) sections from two cases with benign perifissural nodules. Note the smooth margins and the normal undisturbed adjacent fissure

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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16

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a left upper lobe peripheral nodule with several pleural ‘tags’ and element of retraction of the adjacent pleura. Resection histopathology confirmed a well-differentiated squamous cell lung cancer

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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17

Assessment of solitary pulmonary nodule

Initial approach to solid pulmonary nodules

Callister MEJ et al. Thorax 2015;70:ii1-ii54; used with permission

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1

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a right upper lobe posterior cavitating nodule, with biopsy confirming granulomatosis with polyangiitis

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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18

Assessment of solitary pulmonary nodule

Solid pulmonary nodule surveillance algorithm. VDT, volume doubling time

Callister MEJ et al. Thorax 2015;70:ii1-ii54; used with permission

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14

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing examples of malignant perifissural nodules. Note the spiculated edge of the nodules and the evident retraction of the adjacent fissure. Both resection tissue analyses confirmed adenocarcinoma of lung

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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23

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a small peripheral triangular nodule in the right lower lobe, consistent with an intrapulmonary lymph node

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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21

Assessment of solitary pulmonary nodule

PET CT scan with 18-fluorodeoxyglucose (18-FDG) showing a high uptake peripheral left lung lesion. Surgical resection confirmed a moderately differentiated squamous cell lung cancer

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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12

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a small left upper lobe nodule with smooth margins, subsequently found to be a solitary colorectal metastasis on resection

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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9

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a right upper lobe spiculated solitary nodule within emphysema, in a current smoker with previous asbestos exposure. Note the visible pleural plaque on the left side. Resection histology revealed adenocarcinoma of the lung

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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3

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing two areas (red circles) of mucoid impaction of the left upper lobe subsegmental bronchi, resulting in appearance that mimics a nodule

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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20

Assessment of solitary pulmonary nodule

PET CT scan with 18-fluorodeoxyglucose (18-FDG) showing a low uptake in a semi-solid right upper lobe posterior lesion. Surgical resection confirmed adenocarcinoma with primarily lepidic pattern

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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15

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a left upper lobe spiculated nodule with a pleural ‘tag’. Resection histopathology confirmed a moderately-differentiated squamous cell lung cancer

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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22

Assessment of solitary pulmonary nodule

Computed tomography (CT) section with soft tissue configuration, showing a right lung hamartoma, as incidental finding in an asymptomatic patient. Note the central calcification and several small spots of fat within the nodule. This nodule was stable over a 12 year period and no intervention required

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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11

Assessment of solitary pulmonary nodule

Computed tomography (CT) sections with examples of semi-solid solitary nodules

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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7

Assessment of solitary pulmonary nodule

A-D: calcification patterns of benign nodules; E, F: may be seen in malignant nodules

Mazzone P.J., Stoller J.K. Semin Thorac Cardiovasc Surg. 2002;14:250-260; used with permission

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5

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a left upper lobe peripheral elongated nodule, with contrast enhancement and a clear feeding and draining side, consistent with a small arteriovenous malformation

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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4

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing two left lower lobe peripheral nodules (one slightly spiculated and the other with smoother margins) in a patient presenting with fever, high inflammatory serum markers, and blood cultures confirming Streptococcus intermedius. Both nodules completely resolved following a course of linezolid, consistent with septic emboli

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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24

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a posterior left upper lobe spiculated nodule, with ‘bronchus sign’ in a female non-smoker. Bronchoscopic forceps biopsy and brushing assisted by radial EBUS miniprobe localisation, confirmed a non-Hodgkin’s lymphoma

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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8

Assessment of solitary pulmonary nodule

Computed tomography (CT) showing a benign calcified granuloma in the right middle lobe, stable >10 years. The patient reported previous pneumonia on the same side

From the collection of Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert; used with permission

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19

Assessment of solitary pulmonary nodule

Sub-solid pulmonary nodules algorithm. PSNs, part solid nodules; SSN, sub-solid nodules

Callister MEJ et al. Thorax 2015;70:ii1-ii54; used with permission

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