Epidemiology
Hyperinsulinaemic hypoglycaemia is rare in the general population, while iatrogenic or factitious hypoglycaemia is a far more common occurrence among those with access to glucose-lowering agents. The incidence of insulinoma is estimated to be between 0.7 and 4 cases per million per year.[6] One large cohort study found the median age at time of surgery for an insulinoma to be 47 years, with 59% female preponderance. Males and females had no variation with respect to age at time of diagnosis or surgery.[7] People undergoing gastric bypass surgery have been noted to have an increased incidence of hypoglycaemia due to inappropriate insulin response in the setting of altered gastric and jejunal emptying.[8]
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