Criteria
International Society on Thrombosis and Haemostasis Subcommittee on von Willebrand Factor[1]
A bleeding disorder caused by inherited defects in the concentration, structure, or function ofvon Willebrand factor. Classified by types: 1, 2A, 2B, 2M, 2N, and 3.
National Heart Lung and Blood Institute consensus guidelines for the diagnosis and treatment of von Willebrand disease[19]
Diagnosis based on personal bleeding history, family history, and laboratory values.
The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology[18]
Diagnosis focused on practical consequences for management. Distinguishes VWD from those with low VWF as a risk factor for bleeding. When VWF activity is in the range 0.3-0.5 international units (IU)/mL, it should not prompt diagnosis of VWD in the absence of a bleeding history.
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