Superficial vein thrombosis

Topical treatments

There are currently insufficient data to assess the safety and efficacy of topical treatments (e.g., heparin, non-steroidal anti-inflammatory drugs [NSAIDs]) in superficial vein thrombosis (SVT).[70]Di Nisio M, Wichers IM, Middeldorp S. Treatment for superficial thrombophlebitis of the leg. Cochrane Database Syst Rev. 2018 Feb 25;(2):CD004982. http://cochranelibrary-wiley.com/doi/10.1002/14651858.CD004982.pub6/full http://www.ncbi.nlm.nih.gov/pubmed/29478266?tool=bestpractice.com ​ Topical NSAIDs have been used and may have some effect in alleviation of pain and local inflammatory signs, especially in small SVT of varicose veins, but their use is controversial.[44]Beyer-Westendorf J. Controversies in venous thromboembolism: to treat or not to treat superficial vein thrombosis. Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):223-30. https://ashpublications.org/hematology/article/2017/1/223/21080/Controversies-in-venous-thromboembolism-to-treat http://www.ncbi.nlm.nih.gov/pubmed/29222259?tool=bestpractice.com ​[84]Bergqvist D, Brunkwall J, Jensen N, et al. Treatment of superficial thrombophlebitis: a comparative trial between placebo, Hirudoid cream and piroxicam gel. Ann Chir Gynaecol. 1990;79(2):92-6. http://www.ncbi.nlm.nih.gov/pubmed/1696799?tool=bestpractice.com