Course of illness
Patients typically have BDD for up to 15 years before receiving mental health treatment.[89]Neziroglu, F, Lippman, N. A review of body dysmorphic disorder after 20 years of research. Aus Clin Psych. 2015;1(1):22-9. BDD is typically chronic unless it is effectively treated. During up to 4 years of prospective follow-up, the cumulative probability for full remission is only 0.20 and for full or partial remission is 0.55.[90]Phillips KA, Menard W, Quinn E, et al. A 4-year prospective observational follow-up study of course and predictors of course in body dysmorphic disorder. Psychol Med. 2013 May;43(5):1109-17.
http://www.ncbi.nlm.nih.gov/pubmed/23171833?tool=bestpractice.com
More severe BDD symptoms, longer lifetime duration of BDD, and being an adult all confer a lower likelihood of full or partial remission.[90]Phillips KA, Menard W, Quinn E, et al. A 4-year prospective observational follow-up study of course and predictors of course in body dysmorphic disorder. Psychol Med. 2013 May;43(5):1109-17.
http://www.ncbi.nlm.nih.gov/pubmed/23171833?tool=bestpractice.com
Among individuals who partially or fully remit from BDD, the cumulative probability for subsequent full relapse is 0.42 and for subsequent full or partial relapse is 0.63.[90]Phillips KA, Menard W, Quinn E, et al. A 4-year prospective observational follow-up study of course and predictors of course in body dysmorphic disorder. Psychol Med. 2013 May;43(5):1109-17.
http://www.ncbi.nlm.nih.gov/pubmed/23171833?tool=bestpractice.com
Full or partial relapse is predicted by more severe BDD and earlier age at BDD onset.[90]Phillips KA, Menard W, Quinn E, et al. A 4-year prospective observational follow-up study of course and predictors of course in body dysmorphic disorder. Psychol Med. 2013 May;43(5):1109-17.
http://www.ncbi.nlm.nih.gov/pubmed/23171833?tool=bestpractice.com
Of note, most of the participants in this study had not received adequate treatment for BDD.
Prognosis with good treatment
Appropriate pharmacotherapy and cognitive behavioural therapy for BDD results in high response and remission rates.[91]Phillips KA, Keshaviah A, Dougherty DD, et al. Pharmacotherapy relapse prevention in body dysmorphic disorder: a double-blind, placebo-controlled trial. Am J Psychiatry. 2016 Sep 1;173(9):887-95.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009005
http://www.ncbi.nlm.nih.gov/pubmed/27056606?tool=bestpractice.com
[92]Harrison A, Fernández de la Cruz L, Enander J, et al. Cognitive-behavioral therapy for body dysmorphic disorder: a systematic review and meta-analysis of randomized controlled trials. Clin Psychol Rev. 2016 Aug;48:43-51.
http://www.ncbi.nlm.nih.gov/pubmed/27393916?tool=bestpractice.com
Discontinuation of an effective selective serotonin-reuptake inhibitor (SSRI) or clomipramine not uncommonly leads to symptom relapse, and longer-term treatment with these drugs is often (but not always) needed.[91]Phillips KA, Keshaviah A, Dougherty DD, et al. Pharmacotherapy relapse prevention in body dysmorphic disorder: a double-blind, placebo-controlled trial. Am J Psychiatry. 2016 Sep 1;173(9):887-95.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009005
http://www.ncbi.nlm.nih.gov/pubmed/27056606?tool=bestpractice.com
Worsening or relapse of BDD symptoms may occur when effective pharmacotherapy is continued, but clinical observations suggest that this is usually due to medication non-adherence and that improving adherence usually improves symptoms again.[91]Phillips KA, Keshaviah A, Dougherty DD, et al. Pharmacotherapy relapse prevention in body dysmorphic disorder: a double-blind, placebo-controlled trial. Am J Psychiatry. 2016 Sep 1;173(9):887-95.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009005
http://www.ncbi.nlm.nih.gov/pubmed/27056606?tool=bestpractice.com
Following successful cognitive behavioural therapy for BDD treatment, symptom improvement is usually maintained over the first 6-12 months post-treatment.[77]Veale D, Anson M, Miles S, et al. Efficacy of cognitive behaviour therapy versus anxiety management for body dysmorphic disorder: a randomised controlled trial. Psychother Psychosom. 2014;83(6):341-53.
https://karger.com/pps/article/83/6/341/282884/Efficacy-of-Cognitive-Behaviour-Therapy-versus
http://www.ncbi.nlm.nih.gov/pubmed/25323062?tool=bestpractice.com
[79]Wilhelm S, Phillips KA, Greenberg JL, et al. Efficacy and posttreatment effects of therapist-delivered cognitive behavioral therapy vs supportive psychotherapy for adults with body dysmorphic disorder: a randomized clinical trial. JAMA Psychiatry. 2019 Apr 1;76(4):363-73.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450292
http://www.ncbi.nlm.nih.gov/pubmed/30785624?tool=bestpractice.com
[93]Krebs G, Fernández de la Cruz L, Monzani B, et al. Long-term outcomes of cognitive-behavioral therapy for adolescent body dysmorphic disorder. Behav Ther. 2017 Jul;48(4):462-73.
https://www.sciencedirect.com/science/article/pii/S0005789417300023
http://www.ncbi.nlm.nih.gov/pubmed/28577583?tool=bestpractice.com
Over a longer follow-up period (years), many patients maintain their improvement, but a significant number of patients maintain chronic symptoms after treatment; these patients may need a longer-term or more complex intervention and medication treatment.[94]Veale D, Miles S, Anson M. Long-term outcome of cognitive behavior therapy for body dysmorphic disorder: a naturalistic case series of 1 to 4 years after a controlled trial. Behav Ther. 2015 Nov;46(6):775-85.
http://www.ncbi.nlm.nih.gov/pubmed/26520220?tool=bestpractice.com