Other presentations
Common symptoms of alcohol withdrawal include anxiety, nausea or vomiting, autonomic dysfunction, and insomnia.[1]National Institute for Health and Care Excellence. Alcohol-use disorders: diagnosis and clinical management of alcohol-related physical complications. April 2017 [internet publication].
https://www.nice.org.uk/guidance/cg100
[2]Royal College of Physicians. Alcohol dependence and withdrawal in the acute hospital. June 2012 [internet publication].
https://www.rcplondon.ac.uk/guidelines-policy/alcohol-dependence-and-withdrawal-acute-hospital
[3]Bråthen G, Ben-Menachem E, Brodtkorb E, et al. Chapter 29: alcohol-related seizures. In: Gilhus NE, Barnes MP, Brainin M, eds. European handbook of neurological management. 2nd ed, vol 1. Oxford, UK: Blackwell publishing; 2011:429-36.
https://www.eaneurology.org/fileadmin/user_upload/guidline_papers/EFNS_guideline_2011_Alcohol-related_seizures.pdf
Mild to moderate withdrawal symptoms may start as early as 6 to 24 hours after the patient's last alcoholic drink, and peak at 24 to 36 hours.[2]Royal College of Physicians. Alcohol dependence and withdrawal in the acute hospital. June 2012 [internet publication].
https://www.rcplondon.ac.uk/guidelines-policy/alcohol-dependence-and-withdrawal-acute-hospital
[4]Parker AJ, Marshall EJ, Ball DM. Diagnosis and management of alcohol use disorders. BMJ. 2008 Mar 1;336(7642):496-501.
http://www.ncbi.nlm.nih.gov/pubmed/18310004?tool=bestpractice.com
[5]Reus VI, Fochtmann LJ, Bukstein O, et al. The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder. Am J Psychiatry. 2018 Jan 1;175(1):86-90.
https://psychiatryonline.org/doi/pdf/10.1176/appi.books.9781615371969
http://www.ncbi.nlm.nih.gov/pubmed/29301420?tool=bestpractice.com
[7]Tiglao SM, Meisenheimer ES, Oh RC. Alcohol withdrawal syndrome: Outpatient management. Am Fam Physician. 2021 Sep 1;104(3):253-62.
http://www.ncbi.nlm.nih.gov/pubmed/34523874?tool=bestpractice.com
Alcohol withdrawal delirium (also known as delirium tremens) is a life-threatening feature of severe alcohol withdrawal and generally occurs 48 to 72 hours after the last alcoholic drink, and peaks at 5 days.[7]Tiglao SM, Meisenheimer ES, Oh RC. Alcohol withdrawal syndrome: Outpatient management. Am Fam Physician. 2021 Sep 1;104(3):253-62.
http://www.ncbi.nlm.nih.gov/pubmed/34523874?tool=bestpractice.com
Alcohol withdrawal delirium is characterised by hallucinations, delusions, profound confusion and delirium, coarse tremor, and features of clinical instability.[8]McMicken DB, Finnell JT. Alcohol related disease. In: Rosen's emergency medicine: concepts and clinical practice. 6th ed. St. Louis, MO: Mosby, Inc; 2006:184.[9]Schuckit MA. Recognition and management of withdrawal delirium (delirium tremens). N Engl J Med. 2014 Nov 27;371(22):2109-13.
http://www.ncbi.nlm.nih.gov/pubmed/25427113?tool=bestpractice.com
[10]Day E, Copello A, Hull M. Assessment and management of alcohol use disorders. BMJ. 2015 Feb 19;350:h715.
http://www.ncbi.nlm.nih.gov/pubmed/25698774?tool=bestpractice.com
Alcohol withdrawal seizures are also a feature of severe withdrawal, and normally occur in the first 12 to 24 hours after the last alcoholic drink.[10]Day E, Copello A, Hull M. Assessment and management of alcohol use disorders. BMJ. 2015 Feb 19;350:h715.
http://www.ncbi.nlm.nih.gov/pubmed/25698774?tool=bestpractice.com