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Last reviewed: 16 Mar 2025
Last updated: 19 Dec 2023

Summary

Definition

History and exam

Key diagnostic factors

  • abdominal pain
  • anorexia
  • nausea and vomiting
  • right lower quadrant tenderness
  • high’ or ‘intermediate’ risk score
  • tense, rigid abdomen
  • hypotension and tachycardia
  • palpable mass

Other diagnostic factors

  • age of occurrence
  • low-grade pyrexia
  • flushed face and a fetor
  • reduced bowel sounds
  • tachycardia
  • loose stool
  • constipation
  • flexed right hip (psoas sign)

Risk factors

  • improved personal hygiene
  • smoking

Diagnostic investigations

1st investigations to order

  • FBC
  • CRP
  • abdominal ultrasound
  • contrast-enhanced abdominal CT

Investigations to consider

  • urinalysis
  • pregnancy test
  • group and save
  • abdominal MRI

Emerging tests

  • neutrophil-to-lymphocyte ratio
  • serum sodium
  • Pentraxin-3
  • serum amyloid A
  • platelet indices

Treatment algorithm

Contributors

Expert advisers

John Abercrombie, FRCS

General and Colorectal Surgeon

Queen’s Medical Centre

Nottingham

UK

Biography

JA is Clinical Lead for General Surgery, Getting It Right First Time.

Disclosures

JA is trustee and council member of the Royal College of Surgeons of England.

Acknowledgements

BMJ Best Practice would like to gratefully acknowledge the previous expert contributor, whose work is retained in parts of the content:

Dileep N. Lobo, MS, DM, FRCS, FACS

Professor of Gastrointestinal Surgery

National Institute for Health Research, Nottingham Digestive Diseases Biomedical Research Unit

Nottingham University Hospitals and University of Nottingham, Queen's Medical Centre

Nottingham

UK

DNL declares that he has no competing interests. DNL is an author of an article cited in the topic.

Peer reviewers

Sarah Richards

General Surgeon

Royal United Hospitals

Bath NHS Foundation Trust

UK

Biography

SR is a specialty advisor in emergency general surgery to the Royal College of Surgeons and an honorary senior clinical lecturer and examiner for the University of Bristol medical school.

Disclosures

SR declares that she has no competing interests.

Kokila Lakhoo, PhD, FRCS, FCS (Paediatrics) MRCPCH, MBCHB

Consultant Paediatric Surgeon

Children’s Hospital in Oxford and the University of Oxford

UK

Disclosures

KL declares that she has no competing interests.

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