Basal cell carcinoma (BCC) is the most common malignancy of the skin in white adults in the US, Australia, and Europe, and its incidence is increasing.[12]Hu W, Fang L, Ni R, et al. Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years. BMC Cancer. 2022 Jul 30;22(1):836.
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09940-3
http://www.ncbi.nlm.nih.gov/pubmed/35907848?tool=bestpractice.com
[13]Trakatelli M, Morton C, Nagore E, et al. Update of the European guidelines for basal cell carcinoma management. Eur J Dermatol. 2014 May-Jun;24(3):312-29.
http://www.ncbi.nlm.nih.gov/pubmed/24723647?tool=bestpractice.com
CRUK Cancer incidence statistics
Opens in new window BCC occurs in all ethnicities, and it may be missed in Asian and black skin.[14]Maybury CM, Craythorne E, Martin B. An ulcerated nodule on the nose. BMJ Case Rep. 2013 Apr 16;2013:bcr2012008296.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644923
http://www.ncbi.nlm.nih.gov/pubmed/23595174?tool=bestpractice.com
BCC may not be reported to cancer registries or, when it is, may be recorded under the term 'non-melanoma skin cancer'.[15]Ciążyńska M, Kamińska-Winciorek G, Lange D, et al. The incidence and clinical analysis of non-melanoma skin cancer. Sci Rep. 2021 Feb 22;11(1):4337.
https://www.nature.com/articles/s41598-021-83502-8
http://www.ncbi.nlm.nih.gov/pubmed/33619293?tool=bestpractice.com
[16]Rogers HW, Weinstock MA, Feldman SR, et al. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the U.S. population, 2012. JAMA Dermatol. 2015 Oct;151(10):1081-6.
https://jamanetwork.com/journals/jamadermatology/fullarticle/2281227
http://www.ncbi.nlm.nih.gov/pubmed/25928283?tool=bestpractice.com
Determining the exact incidence of BCC is therefore difficult. Using procedure rate code numbers from a US Medicare dataset and claims filed for approved procedures with associated ICD-9-CM (International Classification of Diseases Ninth Revision) diagnosis codes, the 2012 age-adjusted procedure rate for BCC was estimated to be 3280 per 100,000 beneficiaries.[16]Rogers HW, Weinstock MA, Feldman SR, et al. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the U.S. population, 2012. JAMA Dermatol. 2015 Oct;151(10):1081-6.
https://jamanetwork.com/journals/jamadermatology/fullarticle/2281227
http://www.ncbi.nlm.nih.gov/pubmed/25928283?tool=bestpractice.com
The incidence in the UK has been estimated at 128 new cases per 100,000 population in males and 105 per 100,000 in females. The annual incidence in Australia is higher: 2058 per 100,000 in males and 1195 per 100,000 in females.[4]Lear W, Dahlke E, Murray CA. Basal cell carcinoma: review of epidemiology, pathogenesis, and associated risk factors. J Cutan Med Surg. 2007 Jan-Feb;11(1):19-30.
http://www.ncbi.nlm.nih.gov/pubmed/17274935?tool=bestpractice.com