Cochrane Clinical Answers

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Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.

  • How do alpha2-adrenergic agonists compare with placebo or methadone for management of opioid withdrawal?
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  • How does buprenorphine compare with methadone or adrenergic agonists in people undergoing opioid withdrawal?
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  • What are the effects of psychosocial treatments as an adjunct to pharmacological treatments in people undergoing opioid detoxification?
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  • What are the benefits and harms of buprenorphine maintenance versus placebo or methadone maintenance in people with opioid dependence?
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  • What are the benefits and harms of opioid agonist treatment for people who are dependent on pharmaceutical opioids?
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  • For individuals with opiate use disorders, what are the effects of dihydrocodeine for detoxification?
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