When viewing this topic in a different language, you may notice some differences in the way the content is structured, but it still reflects the latest evidence-based guidance.

Last reviewed: 16 Mar 2025
Last updated: 11 Oct 2024

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • left lower quadrant abdominal pain
  • leukocytosis
  • fever
  • rectal bleeding

Other diagnostic factors

  • guarding in left lower quadrant
  • tenderness in left lower quadrant
  • bloating
  • constipation
  • pelvic tenderness on digital rectal examination
  • diffuse abdominal tenderness
  • diarrhoea
  • palpable abdominal mass

Risk factors

  • age >50 years
  • low dietary fibre
  • diet rich in salt, meat, and sugar
  • obesity (BMI >30)
  • tobacco smoking
  • non-steroidal anti-inflammatory drug and opioid use

Diagnostic investigations

1st investigations to order

  • FBC with differential
  • urea and electrolytes
  • C-reactive protein

Investigations to consider

  • contrast CT scan of abdomen
  • non-contrast CT scan of abdomen
  • abdominal ultrasound (graded-compression)
  • MRI
  • chest x-ray
  • colonoscopy
  • sigmoidoscopy
  • CT angiogram
  • isotope-labelled red blood cell nuclear scan
  • diagnostic laparoscopy
  • blood culture
  • ABG and serum lactate

Treatment algorithm

Contributors

Expert advisers

Mohamed A. Thaha, PhD, FRCS (Gen Surg), PG Cert Hlt Econ

Senior Lecturer & Consultant in Colorectal Surgery

National Bowel Research Centre

Blizard Institute

Barts and The London School of Medicine and Dentistry

The Royal London Hospital

Queen Mary, University of London

London

UK

Disclosures

MAT declares that he has no competing interests.

Jayan Dewanta Jayasinghe, MD

Locum Consultant in General & Colorectal Surgery

The Royal London Hospital

Barts Health NHS Trust

London

UK

Disclosures

JDJ declares that he has no competing interests.

Acknowledgements

BMJ Best Practice would like to gratefully acknowledge the previous team of expert contributors, whose work has been retained in parts of the content.

Peer reviewers

John Abercrombie, FRCS

General and Colorectal Surgeon

Queen’s Medical Centre

Nottingham

UK

Biography

JA is a former Clinical Lead for General Surgery, Getting It Right First Time.

Disclosures

JA is a council member of the Royal College of Surgeons of England.

Use of this content is subject to our disclaimer