Prevalence: ADHD is one of the most common disorders of childhood. One high quality estimate of global prevalence in children gives a figure of around 5.29%.[12]Polanczyk G, de Lima MS, Horta BL, et al. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007 Jun;164(6):942-8.
https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.2007.164.6.942
http://www.ncbi.nlm.nih.gov/pubmed/17541055?tool=bestpractice.com
[13]Polanczyk GV, Salum GA, Sugaya LS, et al. Annual research review: a meta-analysis of the worldwide prevalence of mental disorders in children and adolescents. J Child Psychol Psychiatry. 2015 Mar;56(3):345-65.
http://www.ncbi.nlm.nih.gov/pubmed/25649325?tool=bestpractice.com
In the US, a large national survey of parents during 2016-2019, found an overall prevalence of 2% among children aged 3-5 years, of 10% in children aged 6-11 years, and of 13% in children aged 12-17 years.[14]Centers for Disease Control and Prevention. Data and statistics about ADHD. Oct 2023 [internet publication].
https://www.cdc.gov/ncbddd/adhd/data.html
Although prevalence appears to have increased substantially in recent decades, follow-up meta-regression analyses suggest that this difference is due to methodological differences between studies and that, in fact, prevalence has remained stable worldwide (and within specific populations) since the 1980s.[12]Polanczyk G, de Lima MS, Horta BL, et al. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007 Jun;164(6):942-8.
https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.2007.164.6.942
http://www.ncbi.nlm.nih.gov/pubmed/17541055?tool=bestpractice.com
[15]Polanczyk GV, Willcutt EG, Salum GA, et al. ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis. Int J Epidemiol. 2014 Apr;43(2):434-42.
https://academic.oup.com/ije/article/43/2/434/679550
http://www.ncbi.nlm.nih.gov/pubmed/24464188?tool=bestpractice.com
[16]Collishaw S. Annual research review: Secular trends in child and adolescent mental health. J Child Psychol Psychiatry. 2015 Mar;56(3):370-93.
http://www.ncbi.nlm.nih.gov/pubmed/25496340?tool=bestpractice.com
Presentations: the combined-type presentation accounts for 50% to 75% of all people with ADHD, the inattentive-type presentation accounts for 20% to 30%, and the hyperactive-impulsive-type presentation accounts for 15%. Over time, inattentive symptoms tend to persist and hyperactive-impulsive symptoms tend to diminish.[10]Spencer TJ, Biederman MD, Mick E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. J Pediatr Psychol. 2007 Aug;32(8):631-42.
http://www.ncbi.nlm.nih.gov/pubmed/17556405?tool=bestpractice.com
Sex disparities: community studies show male-to-female prevalence rates of around 2.1 to 1.0, while clinic populations show the ratio as high as 10 to 1.[14]Centers for Disease Control and Prevention. Data and statistics about ADHD. Oct 2023 [internet publication].
https://www.cdc.gov/ncbddd/adhd/data.html
[17]Biederman J, Faraone SV. The Massachusetts General Hospital studies of gender influences on attention-deficit/hyperactivity disorder in youth and relatives. Psychiatr Clin North Am. 2004 Jun;27(2):225-32.
http://www.ncbi.nlm.nih.gov/pubmed/15063995?tool=bestpractice.com
This sex difference has been explained by the fact that boys present more often with disruptive behaviour that prompts referral, whereas girls more commonly have the inattentive presentation and have lower comorbidity with oppositional defiant disorder (ODD) and conduct disorder.[10]Spencer TJ, Biederman MD, Mick E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. J Pediatr Psychol. 2007 Aug;32(8):631-42.
http://www.ncbi.nlm.nih.gov/pubmed/17556405?tool=bestpractice.com
[17]Biederman J, Faraone SV. The Massachusetts General Hospital studies of gender influences on attention-deficit/hyperactivity disorder in youth and relatives. Psychiatr Clin North Am. 2004 Jun;27(2):225-32.
http://www.ncbi.nlm.nih.gov/pubmed/15063995?tool=bestpractice.com
It is therefore likely that ADHD is under-recognised and underdiagnosed in girls.[18]Sayal K, Prasad V, Daley D, et al. ADHD in children and young people: prevalence, care pathways, and service provision. Lancet Psychiatry. 2018 Feb;5(2):175-86.
http://www.ncbi.nlm.nih.gov/pubmed/29033005?tool=bestpractice.com
Ethnic differences: several large studies suggest that Hispanic and Asian children have a lower prevalence of ADHD than white or black American children.[14]Centers for Disease Control and Prevention. Data and statistics about ADHD. Oct 2023 [internet publication].
https://www.cdc.gov/ncbddd/adhd/data.html
[19]Cuffe SP, Moore CG, McKeown RE. Prevalence and correlates of ADHD symptoms in the National Health Interview Survey. J Atten Disord. 2005 Nov;9(2):392-401.
http://www.ncbi.nlm.nih.gov/pubmed/16371662?tool=bestpractice.com
According to the Multimodal Treatment Study of AD/HD (MTA), there were higher reported levels of ADHD in the classroom for African-American than for white children.[20]Epstein JN, Willoughby M, Valencia EY, et al. The role of children's ethnicity in the relationship between teacher ratings of attention-deficit/hyperactivity disorder and observed classroom behavior. J Consult Clin Psychol. 2005 Jun;73(3):424-34.
http://www.ncbi.nlm.nih.gov/pubmed/15982140?tool=bestpractice.com
The prevalence of ADHD in black adolescents under 18 years old in the US was reported as 14% in one large meta-analysis, a substantially higher rate than the general US population.[21]Cénat JM, Blais-Rochette C, Morse C, et al. Prevalence and risk factors associated with attention-deficit/hyperactivity disorder among US black individuals: a systematic review and meta-analysis. JAMA Psychiatry. 2021 Jan 1;78(1):21-8.
https://www.doi.org/10.1001/jamapsychiatry.2020.2788
http://www.ncbi.nlm.nih.gov/pubmed/32902608?tool=bestpractice.com
It is unclear if these findings represent actual prevalence differences or whether they may be related to confounding variables such as access to care.
Class and income differences: ADHD has been associated with poverty, lower family income, and lower social class in the US, the UK, and other countries.[22]Langley K, Holmans PA, van den Bree MB, et al. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of attention deficit hyperactivity disorder and associated antisocial behavior: investigation in a clinical sample. BMC Psychiatry. 2007 Jun 20;7:26.
https://bmcpsychiatry.biomedcentral.com/articles/10.1186/1471-244X-7-26
http://www.ncbi.nlm.nih.gov/pubmed/17584500?tool=bestpractice.com
Comorbidity with other mental, emotional, or behavioural disorders is common. According to a 2016 national parent survey in the US, 6 in 10 children with ADHD had at least one co-existing disorder. In about half of children, this was a behaviour or conduct problem. About 3 in 10 children had anxiety. Other comorbidities include depression, autism spectrum disorder, Tourette's syndrome, and learning and language disabilities.[14]Centers for Disease Control and Prevention. Data and statistics about ADHD. Oct 2023 [internet publication].
https://www.cdc.gov/ncbddd/adhd/data.html
[23]DuPaul GJ, Gormley MJ, Laracy SD. Comorbidity of LD and ADHD: implications of DSM-5 for assessment and treatment. J Learn Disabil. 2013 Jan-Feb;46(1):43-51.
http://www.ncbi.nlm.nih.gov/pubmed/23144063?tool=bestpractice.com
Children with epilepsy are at increased risk for cognitive and behavioural disorders including ADHD. While the reported prevalence rates vary depending on study population and methods, clinical-based studies commonly report ADHD in 25% to 40% of children with epilepsy.[24]Dunn DW, Bourgeois BFD. Learning disabilities and ADHD in children with epilepsy. In: Duchowny M, Cross JH, Arzimanoglou A, eds. Pediatric epilepsy. New York, NY: McGraw Hill Medical; 2013:323-9. Adolescents with ADHD are at increased risk of eating disorders and substance use disorders, including alcohol use disorder, cannabis use disorder, and other drug use disorders.[25]Yao S, Kuja-Halkola R, Martin J, et al. Associations between attention-deficit/hyperactivity disorder and various eating disorders: a Swedish nationwide population study using multiple genetically informative approaches. Biol Psychiatry. 2019 Oct 15;86(8):577-86.
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(19)31371-X/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/31301758?tool=bestpractice.com
[26]Groenman AP, Janssen TWP, Oosterlaan J. Childhood psychiatric disorders as risk factor for subsequent substance abuse: a meta-analysis. J Am Acad Child Adolesc Psychiatry. 2017 Jul;56(7):556-69.
http://www.ncbi.nlm.nih.gov/pubmed/28647007?tool=bestpractice.com
[27]Fuller-Thomson E, Lewis DA, Agbeyaka S. Attention-deficit/hyperactivity disorder and alcohol and other substance use disorders in young adulthood: findings from a Canadian nationally representative survey. Alcohol Alcohol. 2022 May 10;57(3):385-95.
https://academic.oup.com/alcalc/article/57/3/385/6336025
http://www.ncbi.nlm.nih.gov/pubmed/34343246?tool=bestpractice.com
There is some evidence that pharmacological treatment for ADHD decreases the risk for substance use disorders.[28]Wilens TE, Faraone SV, Biederman J, et al. Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics. 2003 Jan;111(1):179-85.
http://www.ncbi.nlm.nih.gov/pubmed/12509574?tool=bestpractice.com
[29]Wilens TE, Morrison NR. The intersection of attention-deficit/hyperactivity disorder and substance abuse. Curr Opin Psychiatry. 2011 Jul;24(4):280-5.
http://www.ncbi.nlm.nih.gov/pubmed/21483267?tool=bestpractice.com