When viewing this topic in a different language, you may notice some differences in the way the content is structured, but it still reflects the latest evidence-based guidance.

Last reviewed: 14 Mar 2025
Last updated: 01 Nov 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • abdominal pain
  • alteration of bowel habits associated with pain
  • abdominal bloating or distension
  • normal examination of abdomen

Other diagnostic factors

  • passage of mucus with stool
  • urgency of defecation

Risk factors

  • physical and sexual abuse
  • post-traumatic stress disorder (PTSD)
  • age <50 years
  • female sex
  • previous enteric infection
  • family history
  • family and job stress

Diagnostic investigations

Investigations to consider

  • faecal occult blood test
  • quantitative faecal immunochemical test (FIT)
  • serologic tests for coeliac disease
  • faecal calprotectin
  • faecal lactoferrin
  • serum C-reactive protein (CRP)
  • erythrocyte sedimentation rate (ESR)
  • serum fibroblast growth factor 19
  • 23‐seleno‐25‐homotaurocholic acid (SeHCAT) test
  • 48-hour stool collection for total bile acids
  • empiric trial of bile acid binder
  • hydrogen/methane breath test
  • stool tests for Giardia lamblia
  • plain abdominal x-ray
  • colonoscopy
  • flexible sigmoidoscopy

Treatment algorithm

Contributors

Authors

Ned Snyder, MD, MACP, AGAF

Professor of Medicine

Baylor College of Medicine and Marion DeBakey VA Hospital

Houston

TX

Adjunct Professor of Medicine

University of Texas Medical Branch

Galveston

TX

Disclosures

NS declares that he is a member on the board of the Kelsey Research Foundation, a non-profit organization. Kelsey Research Foundation has received and awarded private grants for the study of the microbiome in several diseases, including irritable bowel syndrome.

Peer reviewers

Douglas Drossman, MD

Professor of Medicine and Psychiatry

School of Medicine

Co-Director

UNC Center for Functional GI and Motility Disorders

Chapel Hill

NC

Disclosures

DD declares that he has no competing interests.

Simon McLaughlin, MBBS

Research Fellow

Department of Gastroenterology

St Mark's Hospital

Northwick Park

Harrow

UK

Disclosures

SM declares that he has no competing interests.

Horace Williams, MBBS

Clinical Research Fellow

Division of Medicine

Imperial College

London

UK

Disclosures

HW declares that he has no competing interests.

Use of this content is subject to our disclaimer