Primary prevention

There is no known preventive treatment for gestational trophoblastic disease (GTD).

Secondary prevention

Women should be advised not to conceive again until post-treatment follow-up is complete.[3][34][54] Women who previously underwent chemotherapy for GTN should be advised not to conceive for 1 year after completion of treatment.[34][54]

Subsequent pregnancies in women with prior gestational trophoblastic disease should be evaluated with early sonographic determination of a normal intrauterine gestation.[3]​ Although controversial, sending material obtained at the end of pregnancy (from an abortion, ectopic pregnancy, or placenta from a preterm/term pregnancy) may be appropriate to exclude cases of repeat GTD. If this is not possible, hCG levels can be measured 6-8 weeks after the end of the pregnancy to detect this serious condition early.[3]

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