Lambert-Eaton myasthenic syndrome

Medications that may exacerbate weakness should be avoided. The most commonly used medications include antibiotics (macrolides, aminoglycosides, fluoroquinolones) and beta-adrenergic receptor blockers. Other medications include iodinated contrast, magnesium, lithium, quinidine, calcium-channel blockers, procainamide, and immune checkpoint inhibitors.[42]Krenn M, Grisold A, Wohlfarth P, et al. Pathomechanisms and clinical implications of myasthenic syndromes exacerbated and induced by medical treatments. Front Mol Neurosci. 2020 Aug 14:13:156. https://www.frontiersin.org/articles/10.3389/fnmol.2020.00156/full http://www.ncbi.nlm.nih.gov/pubmed/32922263?tool=bestpractice.com ​ A complete reference of drugs impairing neuromuscular transmission is available. Myasthenia Gravis Foundation of America: Medications and myasthenia gravis Opens in new window

The patient should be instructed to contact the managing neurologist about any pending surgical procedures to optimise anaesthesia because certain neuromuscular blocking agents used during surgical procedures may result in prolonged weakness. Regular exercise should be advised, although exposure to heat may need to be limited, as fatigue and weakness may worsen. Osteoporosis prophylaxis may be indicated for patients receiving high-dose corticosteroid treatment. See Osteoporosis (Prevention).