Cohort demographics and therapies
| Congenital (n=44) | Non-congenital (n=26) | p Value | |
|---|---|---|---|
| Age (years) | |||
| Mean (SD) | 39 (8.7) | 64 (14.2) | <0.001 |
| Median (IQR) | 39 (32.0–44.8) | 65 (56.5–74.0) | |
| Sex (% men) | 39 | 15 | 0.040 |
| Mortality (% dead) | 30 | 31 | 0.914 |
| Diuretics (%) | 24 | 50 | 0.038 |
| Anticoagulants (%) | 26 | 27 | 0.90 |
| Treated (%) | 61 | 100 | <0.001 |
| Heart–lung transplant (%) | 7 | 4 | 0.605 |
| Peak SPAP (mm Hg) | |||
| Mean (SD) | 117 (14.2) | 110 (25.2) | 0.010 |
| Median (IQR) | 115 (110–124) | 103 (93–120) | |
| 6-min walk distance (m) | |||
| Mean (SD) | 425 (105) | 370 (114) | 0.50 |
| Median (IQR) | 446 (351–485) | 369 (293–437) | |
| WHO functional class (%) | |||
| I | 9 | 0 | <0.001 |
| II | 54 | 12 | |
| III | 35 | 83 | |
| IV | 2 | 0 | |
WHO functional class measured at time of initial referral to centre; 6-min walk distance represents average distance on most recent test. Data represented as percentages (%), mean with SD and/or median with IQR.